White matter microstructure is related to aerobic fitness in treatment-resistant schizophrenia
Oral Presentation C10.3
DOI:
https://doi.org/10.14288/hfjc.v14i3.704Keywords:
Aerobic Fitness, Schizophrenia, White Matter, Myelin Water Fraction, Fractional AnisotropyAbstract
Background: Aerobic fitness may benefit brain white matter (WM) microstructure, which is known to be adversely affected in schizophrenia. Purpose: To examine the relationship between aerobic fitness (VO2max) and WM integrity in treatment-resistant schizophrenia. Methods: Measurements of VO2max and magnetic resonance imaging markers for myelin (myelin water fraction (MWF), radial diffusivity (RD), and axons (fractional anisotropy (FA), axial diffusivity (AD) were obtained from exercise naïve volunteers (n = 15 =schizophrenia/schizoaffective disorder patients, n = 10 healthy age, sex and education matched volunteers). Results: MWF and FA were significantly reduced, and RD was significantly increased in the WM of patients relative to controls. Patient VO2max was significantly associated with MWF, FA, and RD in frontal and temporal WM (r = 0.14 – 0.16, p<0.001). No associations between WM microstructure and VO2max were seen, except in the splenium of healthy volunteers (r = 0.22, p = 0.02). Conclusion: Abnormal WM microstructure in patients appears to be more responsive to exercise intervention in comparison to healthy volunteers, as healthy volunteers may already have optimized WM. Our results suggest that investigating ways to increase aerobic fitness in schizophrenia patients may be a low-risk intervention to improve WM tissue health in treatment-resistant schizophrenia patients. Funding: Grant operating funds to DJL for this study were provided by the Canadian Institutes for Health Research (Grant # 231233-BSB) and the BC Mental Health Authority Research Services.
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Copyright (c) 2021 Peter Senften, Melissa Woodward, Adam Dvorak, Shannon Kolind, Cornelia Laule, Henry P.H. Lai, Kai L. Kaufman, Darren E.R. Warburton, Kristina Gicas, David D. Kim, Wayne Su, Wiliam Honer, Alexander Rauscher, Alexander Rauscher, Donna J. Lang
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