The association of accelerometer-measured sedentary accumulation patterns with Incident Cardiovascular Disease, cancer, and all-cause mortality
Oral Presentation B12.6
DOI:
https://doi.org/10.14288/hfjc.v14i3.573Keywords:
Sedentary, Patterns, Cardiovascular Disease, Cancer, CompositionalAbstract
Background: Emerging evidence suggests accruing sedentary behaviour (SB) in relatively more prolonged periods may convey additional cardiometabolic risks. Purpose: To examine the association of SB accumulation patterns with incident cardiovascular disease (CVD), all-cause mortality (ACM), and incident cancer. Methods: Data were from 7,671 UK middle-to-older-aged adults who wore accelerometers on the right hip for 4-7 days. Cox proportional hazards regression modelled non-linear (spline) associations between two measures of SB accumulation (usual bout duration and alpha [hybrid measure of bout frequency/duration]) and incident CVD, cancer and ACM. Models were adjusted for potential confounders and 24-hour time-use compositions. Results: During mean follow-up time of 6.4 years, 339 ACM, 1,106 CVD, and 516 cancer events occurred. Elevated risk of incident cancer and ACM was seen with more prolonged SB accumulation (lower alpha, higher usual bout duration), but not CVD. For alpha and usual SB bout duration, respectively, the confounder-adjusted hazard ratio (HR: [95% CI]) for 90th vs. 10th percentiles were 0.72 (0.54-0.96) and 1.32 (0.97-1.81) with incident cancer and 0.70 (0.53-0.93) and 1.16 (0.86-1.56) with ACM. Further adjustment for 24-hour time-use weakened associations with ACM for usual bout duration (0.95 [0.68-1.34]) and partially for alpha (0.78 [0.57-1.08]). Conclusions: Accruing SB in longer bout durations was associated non-linearly manner with significant additional increases in risk of cancer and ACM, but not CVD, with some evidence of direct SB accumulation effects independent of 24-hour time-use. Findings provide some support for considering SB accumulation as an adjunct target of messaging to “sit less and move more”. Funding: The European Prospective Investigation into Cancer and Nutrition-Norfolk cohort study (DOI 10.22025/2019.10.105.00004) has received funding from the Medical Research Council (MR/N003284/1 and MC_UU_12015/1) and Cancer Research UK (C864/A14136). TS, KWe, KR, SB, and KWi are supported by the UK Medical Research Council [grant numbers MC_UU_00006/4 and MC_UU_12015/3] and/or the NIHR Cambridge Biomedical Research Centre (IS-BRC-1215-20014).
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Copyright (c) 2021 Paddy C. Dempsey, Tessa Strain, Elisabeth E. Winkler, Kate Westgate, Kirsten Rennie, Nicolas J. Wareham, Søren Brage, Katrien Wijndaele
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