Associations of accelerometer-measured physical activity volume and intensity with Incident Cardiovascular Disease: UK Biobank Study
Oral Presentation B12.5
DOI:
https://doi.org/10.14288/hfjc.v14i3.572Keywords:
Physical Activity, Intensity, Accelerometer, Cardiovascular DiseaseAbstract
Background: The role of physical activity (PA) intensity over and above volume on cardiovascular disease (CVD) risk is insufficiently understood. Purpose: To investigate integrated associations of PA volume/intensity with incident CVD. Methods: Data were from 88,431 adults from UK Biobank (56.3% women) who wore accelerometers on their dominant wrist for 7 days. Cox proportional hazards regression modelled associations between PA volume/day (mg) and the intensity gradient (IG: distribution of intensity: higher/less-negative values indicate proportionately more time at higher intensities) with incident CVD, adjusted for potential confounders. Results: During a median follow-up period of 6.1 years 3,469 CVD events occurred. Both higher PA volume and IG were associated with a lower hazard of incident CVD by 21% (12-29%) and 14% (8-20%), when comparing the 25th (20mg and -2.7) to the 10th percentiles (reference; 14mg and -2.9) of either exposure. In interaction analyses, at a PA volume of 14mg and IG values corresponding to the 25th, 50th and 95th percentiles, hazards were 11% (7-15%), 21% (14-28%), and 30% (20-39%) lower for incident CVD compared to the reference (10th percentile). In stratified analyses, a higher IG was equally beneficial across tertiles of PA volume (HR: ~13-32%, relative to a lower IG). Conclusions: Findings suggest reductions in CVD risk may be achievable through either increasing PA volume or increasing the proportion of time spent at higher PA intensities, with both conferring additive benefits. This supports multiple approaches/strategies to reducing CVD risk, some of which may be more practical or appealing to different individuals. Funding: Research conducted using the UK Biobank Resource under Application Number 33266. TY and accelerometer data processing were supported by the Lifestyle Theme of the Leicester NHR Leicester BRC. TS, SB, and KW are supported by the UK Medical Research Council [grant numbers MC_UU_00006/4 and MC_UU_12015/3].
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Copyright (c) 2021 Paddy C. Dempsey, Alex Rowlands, Tessa Strain, Katrien Wijndaele, Søren Brage, Francesco Zaccardi, Nathan Dawkins, Cameron Razieh, Melanie Davies, Kamlesh Khunti, Thomas Yates
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