Physical activity, sedentary time and cardiorespiratory fitness in patients with heart failure: Isotemporal substitution analysis
Oral Presentation C10.6
DOI:
https://doi.org/10.14288/hfjc.v14i3.707Keywords:
Accelerometry, Isotemporal Substitution, HFpEFAbstract
Background: Previous work has demonstrated that patients with heart failure with preserved ejection fraction (HFpEF) have low physical activity (PA) and high sedentary time (ST), which are associated with cardiorespiratory fitness (CRF). Purpose: To examine the effects of replacing 30 min of ST with light intensity PA (LPA) and moderate- to vigorous- intensity PA (MVPA) on CRF in patients with HFpEF. Methods: Ten patients with HFpEF (mean age 59.1 y, mean BMI 41.4 kg/m2, 40% Black, 100% Women) underwent symptom-limited cardiopulmonary exercise testing on a treadmill. Free-living PA was objectively measured using a waist-worn ActiGraph GT9X accelerometer. Effects of replacing 30 min ST with 30 min LPA or 30 min MVPA on V2O2peak (L/min) were assessed via isotemporal substitution analysis before and after adjusting for age and race. Results: Substituting 30 min ST with 30 min of MVPA resulted in a positive trend for increased V̇O2peak but did not reach statistical significance (unadjusted model: 1.57 L/min, p = 0.085; adjusted model: 1.22 L/min, p = 0.074). The magnitude of change in V2O2peak was higher when MVPA was substituted for ST rather than LPA. Conclusions: Results of this preliminary analysis suggest that replacing ST with MVPA has a greater effect on V̇O2peak compared to substitution with LPA. Randomized controlled trials and studies with larger samples are needed to elucidate the effects of replacing ST with PA on CRF in this population. Funding: Career Development Award (19CDA34660318) from the AHA (Salvatore Carbone); NIH CTSAP (UL1TR002649) at VCU.
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Copyright (c) 2021 Jonathan D. Kenyon, Hayley Billingsley, Natalie Bohmke, Danielle Kirkman, Antonio Abbate, Roshanak Markley, Salvatore Carbone, Youngdeok Kim
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