Associations of physical activity fitness, strength and sedentary behaviours with breast cancer risk: Findings from the UK Biobank prospective cohort study

Mini-Oral Presentation B2.18

Authors

  • Solange Parra-Soto University of Glasgow
  • Craig Tumblety University of Glasgow
  • Frederick K. Ho University of Glasgow
  • Jill P. Pell University of Glasgow
  • Carlos Celis-Morales University of Glasgow; Universidad Mayor; Universidad Catolica del Maule

DOI:

https://doi.org/10.14288/hfjc.v14i3.625

Keywords:

Breast Cancer, Physical Activity, Strength, Cohort-Study

Abstract

Background: Although low physical activity level is associated with breast cancer, evidence of associations with sedentary behaviours and physical fitness/capability is limited. Therefore, this study aimed to investigate of the association of breast cancer with various measures of physical activity, fitness, strength and sedentary behaviours. Methods: Data from 243,004 (60,897 premenopausal and 144,858 postmenopausal) women in the UK Biobank cohort were analysed. Physical activity was assessed using the International Physical Activity Questionnaire (IPAQ) and wrist accelerometers. Handgrip strength was assessed using a hand dynamometer and fitness through a submaximal cycle ergometer test. Hazard ratios (HR) were calculated for all exposure variables, using multivariable-adjusted Cox proportional models. Results: 8,179 incident breast cancers (1,735 premenopausal and 5,163 postmenopausal) were diagnosed during follow-up (mean 8.8 years in the 2-year landmark analysis). Compared with those in the lowest tertiles, women in the highest tertiles of physical activity (HR: 0.95, [95% CI: 0.92; 0.98], ptrend: 0.002), relative grip strength (HR: 0.96 [95%CI: 0.92; 0.99], ptrend: 0.046) self-reported walking (HR: 0.96, 95% CI: 0.93; 0.99, ptrend: 0.009), and moderate PA (HR: 0.96, 95% CI: 0.93; 1.00, ptrend: 0.030) had lower risk of incident breast cancer. Risk of breast cancer was associated with total and moderate PA among premenopausal women and walking pace, total PA, walking, fitness, relative grip strength and sedentary time in postmenopausal women. Conclusion: Physical activity, fitness/capability, strength, and sedentary behaviours are consistently associated with reduced risk of breast cancer in women pre- and post-menopause. Funding: SPS receives financial support from the Chilean Government for doing her PhD (ANID-Becas Chile 2019).

Published

2021-09-30

How to Cite

Parra-Soto, S., Tumblety, C., Ho, F., Pell, J., & Celis-Morales, C. (2021). Associations of physical activity fitness, strength and sedentary behaviours with breast cancer risk: Findings from the UK Biobank prospective cohort study: Mini-Oral Presentation B2.18. The Health & Fitness Journal of Canada, 14(3). https://doi.org/10.14288/hfjc.v14i3.625

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