Associations between maternal physical activity and sedentary behavior and mRNA expression of oxidative stress and vascularization markers in term placenta of obese pregnant women: Findings of the DALI study
Mini-Oral Presentation B2.14
DOI:
https://doi.org/10.14288/hfjc.v14i3.621Keywords:
Physical Activity, Lifestyle Intervention, Obesity, Pregnant Women, Health PromotionAbstract
Background: Maternal obesity can affect placental development, often reflected in changes in oxidative stress and vascularization. Sufficient physical activity and reduced sedentary time might mitigate these effects. Purpose: To test if vascularization and oxidative stress in the placenta of obese pregnant mothers are associated with maternal moderate-to-vigorous physical activity (MVPA) and sedentary time (ST). Methods: This is a contribution to the DALI study including women with a pre-pregnancy body mass index (BMI) ≥29 kg/m2. Time spent in MVPA, and ST were measured with accelerometers at <20 ,24–28 and 35–37 weeks of gestation. Placental tissue was dissected from four quadrants, mRNA isolated and pooled per placenta. Expression of markers of vascularization (VEGF, PEDF, CD34) and oxidative stress (Lp_PLA2, GADD45α, GADD45β, Nrf2, HSP70, HO-1, MT2A) was quantified by NanoString nCounter Technology. In a two-step analysis, changes in MVPA and ST during pregnancy for each woman and average MVPA and ST were entered into multilevel regression models to estimate associations with mRNA expressions. Results: Outcomes were available from 96 women. Higher average maternal ST was only associated with higher expression of the anti-oxidative lipoprotein-associated phospholipase A2 (Lp_PLA2; 0.5; 95% CI 0.1, 0.9). Changes in MVPA or ST over time were not associated with mRNA expression. Conclusions: While no significant association was observed between maternal lifestyle and mRNA expression of the vascularization markers, ST might associate with oxidative stress levels in placenta. To better understand this, serum oxidative stress markers and total antioxidant capacity will be measured in maternal and cord blood. Funding: The DALI project has received funding from the European Community’s 7th Framework Program (FP7/2007–2013) under grant agreement no 242187.
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Saghi Zafaranieh, Anna M. Dieberger, Gernot Desoye, David Simmons, Mireille van Poppel
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Terms of Publication
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the Health & Fitness Journal of Canada’s right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- The Contributor (author(s)) represents and guarantees that the Contributor is the sole proprietor of the work and the Contributor has full power to make this Agreement and grant that the work does not infringe the copyright or other proprietary right of any other person; and the work contains no libellous or other unlawful matter and makes no improper invasion of the privacy of any other person. The Contributor also represents and is responsible for the accuracy of the work.
- The Contributor will read, correct, and return promptly galleys and page proofs to the Editor (or designate). The Contributor will be responsible for the completeness and accuracy of these corrections. If the Contributor does not return galleys and page proofs within the schedule agreed upon with the Editor (or designate), the Publisher may proceed without the Contributor corrections.
- When applicable, the Contributor agrees to obtain written permissions and letters of agreement for all matter contained in the work that is protected by existing copyright, paying any permission fees for the use of text or illustrations controlled by others, and furnishing the Publisher with written evidence of the copyright owner’s authorization to use the material.
- When applicable, the Contributor agrees to obtain written permission for inclusion of any photographic materials involving a human subject, and provide the Publisher with written evidence of the subject’s authorization to use this material. In the case of subjects who have not reached the age of majority, the Contributor agrees to obtain and furnish the Publisher with written permission from the parent and/or legal guardian.
- The Contributor may draw on and refer to material in the work in preparing other articles for publication in scholarly and professional journals and papers for delivery at professional meetings, provided that credit is given to the work and to the Publisher.
- This agreement may not be changed unless the Contributor and the Publisher agree to the change by means of a formal addendum signed by the Contributor and the Publisher’s representative.
- This agreement shall be construed and governed according to the laws of the province of British Columbia and shall be binding upon the parties hereto, their heirs, successors, assigns, and personal representatives. Should any formal proceedings related to this agreement be brought, such formal proceeding may be brought only in the province of British Columbia.
By submitting an article to the Health & Fitness Journal of Canada the Contributor has accepted and agreed to all terms outlined in the copyright notice.
