Standing is associated with insulin sensitivity in adults with metabolic syndrome
Oral Presentation B12.3
DOI:
https://doi.org/10.14288/hfjc.v14i3.570Keywords:
Sedentary Behavior, Physical Activity, Cardiorespiratory Fitness, Insulin Resistance, Metabolic SyndromeAbstract
Background: Physical activity (PA) is a determinant of insulin sensitivity. It is more unclear how sedentary behavior (SB) and patterns of SB associate with insulin sensitivity. Purpose: To determine how SB, breaks in sitting, standing, PA, and fitness are associated with insulin sensitivity in adults with metabolic syndrome. Methods: Sixty-four sedentary adults with metabolic syndrome (mean age 58 years; 37 women) were included. SB, breaks in sitting, standing, and PA were measured for four weeks with accelerometers. VO2max was measured with maximal cycle ergometry. Insulin sensitivity was determined by hyperinsulinaemic-euglycaemic clamp (M-value) and fasting blood sampling (HOMA-IR, insulin). Multivariable regression was used for analyses. Results: Sedentary time, standing, steps, and VO2max were associated with M-value, HOMA-IR, and insulin, while breaks in sitting associated only with M-value. When adjusted for body fat %, only standing remained significantly associated with HOMA-IR and insulin, and significance was maintained even when further adjusted for PA, SB, and fitness (all p-values <0.05). Light and moderate-to-vigorous PA were not associated with insulin sensitivity. Conclusions: Standing is associated with insulin sensitivity markers in sedentary adults. The associations of standing with HOMA-IR and insulin are independent of adiposity, PA, SB, and fitness. Further studies are warranted, but these findings encourage replacing sitting with standing for potential improvements in insulin sensitivity in adults at increased type 2 diabetes risk. Funding: Academy of Finland, Finnish Cultural Foundation, Finnish Diabetes Research Foundation, Hospital District of Southwest Finland, Juho Vainio Foundation.
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Copyright (c) 2021 Taru Garthwaite, Tanja Sjöros, Mikko Koivumäki, Saara Laine, Henri Vähä-Ypyä, Maria Saarenhovi, Petri Kallio, Eliisa Löyttyniemi, Harri Sievänen, Noora Houttu, Kirsi Laitinen, Kari Kalliokoski, Tommi Vasankari, Juhani Knuuti, Ilkka H.A. Heinonen
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