Sitting less does not improve insulin sensitivity in adults with metabolic syndrome - a randomized controlled trial
Oral Presentation B12.2
DOI:
https://doi.org/10.14288/hfjc.v14i3.569Keywords:
Sedentary Behavior, Insulin Resistance, Metabolic Health, AccelerometryAbstract
Background: Sedentary time has been identified as a risk factor for metabolic disorders such as Type 2 Diabetes. However, there are only few published intervention studies concerning the health effects of reducing sedentary time. Purpose: To investigate whether reduced daily sitting, without adding moderate to vigorous physical activity (MVPA) improves insulin sensitivity in 6 months. Methods: Sixty-four sedentary inactive adults with metabolic syndrome (age 58 yrs SD 7; 27 men) were randomized to intervention and control groups. The 6-month individualized behavioral intervention supported by interactive accelerometers aimed at reducing daily sitting time for 1h compared to baseline. Insulin sensitivity by hyperinsulinemic euglycemic clamp and body composition were measured and fasting blood samples drawn at baseline and 6 at months. Mean change differences over time were tested with linear mixed models. Results: Plasma insulin decreased by 1.1 mU/l in average in the intervention group, while the change in the control group was non-significant. Insulin sensitivity did not change during the intervention. Body mass and BMI decreased and HbA1c increased during the intervention while group change differences reached near significance. Body adiposity decreased but not differently between groups. Conclusions: Intervention aiming to reduce daily sedentary time slightly decreased fasting insulin, but had no effects on insulin sensitivity or body adiposity. Therefore, multifaceted interventions targeting both to reduce sedentary time and increase MVPA are likely to be more beneficial. Funding: Study founded by The Finnish Cultural Foundation, Juho Vainio Foundation, The Finnish Diabetes Research Foundation, Yrjö Jahnsson Foundation, Hospital District of Southwest Finland, Turku University Foundation and Finnish Sports Institute Foundation.
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Copyright (c) 2021 Tanja Sjöros, Saara Laine, Taru Garthwaite, Mikko Koivumäki, Henri Vähä-Ypyä, Eliisa Löyttyniemi, Noora houttu, Kirsi Laitinen, Harri Sievänen, Tommi Vasankari, Kari K. Kalliokoski, Juhani Knuuti, Ilkka H.A. Heinonen
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