Sedentary behavior and physical activity are associated with endothelial dysfunction and low-grade inflammation

Oral Presentation B12.1

Authors

  • Evelien J. Vandercappellen Maastricht University
  • Annemarie Koster Maastricht University
  • Hans H. C. M. Savelberg Maastricht University
  • Simone J. P. M. Eussen Maastricht University
  • Pieter C. Dagnelie Maastricht University
  • Nicolaas C. Schaper Maastricht University
  • Miranda T. Schram maast
  • Carla J. H. van der Kallen Maastricht University
  • Marleen M. J. van Greevenbroek Maastricht University
  • Anke Wesselius Maastricht University
  • Casper G. Schalkwijk Maastricht University
  • Abraham A. Kroon Maastricht University
  • Ronald M. A. Henry Maastricht University
  • Coen D. A. Stehouwer Maastricht University

DOI:

https://doi.org/10.14288/hfjc.v14i3.568

Keywords:

Physical Activity, Sedentary Behavior, Endothelial Dysfunction, Low-Grade Inflammation

Abstract

Background: Endothelial dysfunction and low-grade inflammation are important in the pathogenesis of cardiovascular disease and can potentially be modified by physical activity and sedentary behavior and may be especially prominent in type 2 diabetes. Purpose: To study the relationship between physical activity and sedentary behavior on the one hand and endothelial dysfunction and low-grade inflammation on the other. Specifically, the influence of prediabetes and type 2 diabetes. Methods: In the population-based Maastricht Study (n=2363, 28.3% type 2 diabetes) we determined biomarkers of endothelial dysfunction and low-grade inflammation and combined z-score were calculated. Physical activity and sedentary behavior were measured by activPAL. Linear regression analyses were used with adjustment for demographic, lifestyle and cardiovascular risk factors. Results: The association between total, light, moderate-to-vigorous and vigorous physical activity and sedentary time on the one hand and endothelial dysfunction on the other were generally significant and were consistently stronger in prediabetes and type 2 diabetes as compared to normal glucose metabolism status (p-interaction<0.05). Associations between physical activity and sedentary behavior on the one hand and low-grade inflammation on the other were also significant and were similar in individuals with and without (pre)diabetes (p-interaction>0.05). Conclusions: Physical activity and sedentary behavior are associated with endothelial dysfunction and low-grade inflammation. For endothelial dysfunction, associations between physical activity and sedentary behavior were consistently stronger in (pre)diabetes than in normal glucose metabolism. Funding Sources: ERDF, PoL, SDW, PSID, CVC, CARIM, CAPHRI, NUTRIM, SA, HFL, JCBV, NNF, SAN, EFSD/AstraZeneca.

Published

2021-09-30

How to Cite

Vandercappellen, E., Koster, A., Savelberg, H., Eussen, S., Dagnelie, P., Schaper, N., Schram, M., van der Kallen, C., van Greevenbroek, M., Wesselius, A., Schalkwijk, C., Kroon, A., Henry, R., & Stehouwer, C. (2021). Sedentary behavior and physical activity are associated with endothelial dysfunction and low-grade inflammation: Oral Presentation B12.1. The Health & Fitness Journal of Canada, 14(3). https://doi.org/10.14288/hfjc.v14i3.568

Issue

Vol. 14 No. 3 (2021): Proceedings from the 8th International Society for Physical Activity and Health Congress

Section

CONFERENCE PROCEEDINGS

License

Copyright (c) 2021 Evelien J. Vandercappellen, Annemarie Koster, Hans H.C.M. Savelberg, Simone J.P.M. Eussen, Pieter C. Dagnelie, Nicolaas C. Schaper, Miranda T. Schram, Carla J.H. van der Kallen, Marleen M.J. van Greevenbroek, Anke Wesselius, Casper G. Schalkwijk, Abraham A. Kroon, Ronald M.A. Henry, Coen D.A. Stehouwer

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