Associations between device-measured physical activity and incident dementia: a prospective study
Oral Presentation B5.3
DOI:
https://doi.org/10.14288/hfjc.v14i3.515Keywords:
Accelerometer, Dementia, Physical ActivityAbstract
Background: Previous cohort studies have investigated the relationship between self-reported physical activity (PA) and dementia. Evidence from objective device-measured PA data is lacking. Purpose: To investigate the association of device-measured PA with the risk of dementia incidence using the UK Biobank study. Methods: 84,854 participants (55.8% women) were included in this prospective cohort study. Wrist accelerometers were used to measure total, light, moderate, vigorous and moderate-to-vigorous PA (MVPA) in MET/min/week. Nonlinear associations were first investigated using penalised cubic splines fitted in the Cox proportional hazard models. In addition, using MVPA, five categories were created. Associations of these categories with the outcomes were investigated using Cox proportional hazard models. Results: After a median follow-up of 6.3 years, 678 individuals were diagnosed with dementia. Evidence of nonlinearity was observed for all PA modes and all-cause dementia. For categories of MVPA, there was a significant trend towards a low risk of overall dementia when higher levels of MVPA were achieved (HRtrend: 0.66 [95% CI: 0.62 to 0.70]. Individuals who performed more than 1,200 MET/min/week had 84% (95% CI: 0.12 to 0.21) lower risk of incident dementia compared to those who performed <300 MET/min/week. Conclusion: Participants with higher PA levels had a lower risk of incident dementia than those less active, independently of confounding factors. Funding: None.
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Copyright (c) 2021 Fanny Petermann-Rocha, Donald M. Lyall, Stuart R. Gray, Jason M.R. Gill, Naveed Satttar, Paul Welsh, Terence J. Quinn, William Stewart, Jill P Pell, Frederick K. Ho, Carlos Celis-Morales
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