Occupational physical activity in relation to all-cause, CVD, and cancer mortality in 349,248 adults: Prospective & longitudinal analyses of Taiwan's MJ Cohort
Oral Presentation A10.6
DOI:
https://doi.org/10.14288/hfjc.v14i3.423Keywords:
Physical Activity, Mortality, Socioeconomic Status, Confounding, Physical Activity ParadoxAbstract
Background: Previous studies on the health effects of occupational physical activity (OPA) have reported conflicting results. No study has examined the role of changes in OPA over time. Purpose: To examine the associations of baseline OPA and OPA changes with mortality risk. Methods: Baseline OPA was categorized as light (ref)/moderate/moderately heavy/ heavy. OPA changes over time were categorized as stable (ref)/decreased/ increased. We used Cox regression adjusted for a comprehensive set of potential confounders and excluded a) participants with existing CVD/cancer, and b) deaths occurring in the first two years. Results: 349,248 participants (177,314 women) with baseline OPA were followed up for 14.6 (5.1) years. In the age adjusted models, higher OPA showed detrimental associations with all three mortality outcomes in men only [e.g. all-cause mortality (ACM) HR: 1.33, 95%CI: 1.21 to 1.45] for heavy compared to light OPA. Adjustments for confounders reversed the baseline OPA and ACM associations in men (0.92, 0.86 to 0.98 for moderately heavy OPA), and revealed beneficial associations in women (ACM HR 0.87, 0.79 to 0.97). The OPA changes analyses included 105,715 (52,503 women) followed up over 6.3 (4.2) years. Compared to stable OPA, OPA decrease was associated with higher ACM risk in men only (fully adjusted HR: 1.18, 1.00 to 1.38). (Baseline or changes in) OPA showed no associations with CVD or cancer mortality. Conclusions: Higher baseline OPA levels were beneficially associated with ACM risk in men and women, and OPA decreases over time were associated with highest risk in men. Our results support potential health gains through higher OPA. Funding: This work was supported by a NHMRC Investigator Grant (APP1194510).
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Copyright (c) 2021 Emmanuel Stamatakis, Tiana-Lee Elphick, Matthew Ahmadi, Li-Jung Chen, Yun-Ju Lai, Susan Paudel, Po-Wen Ku
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