Changes in physical activity and adiposity with mortality and incidence of cardiovascular disease: Longitudinal findings from the UK Biobank
Oral Presentation A10.2
DOI:
https://doi.org/10.14288/hfjc.v14i3.417Keywords:
Physical Activity, Body Mass Index, Waist Circumference, Cardiovascular Disease, MortalityAbstract
Background: Physical activity (PA) and adiposity are both major causal risk factors for cardiovascular disease (CVD) and all-cause mortality (ACM). Purpose: To examine the associations of concurrent changes in physical activity and adiposity with incident CVD and ACM. Methods: Baseline PA was categorized into inactive, insufficient, and sufficient based on current guidelines. Body mass index (BMI) and waist-to-hip ratio (WHR) were categorised into baseline tertiles. Both exposures were further grouped as decreased, stable, or increased based on changes in category over time. We examined hazard ratios (HR’s) for all-cause mortality using cox regression and cox regression with competing risk for CVD. Results: A total of 2,573 incident CVD events and 471 deaths occurred among 29,494 participants with an average CVD and mortality follow-up of 4.7 (2.2) and 5.1 (2.1) years. Relative to stable PA and BMI or WHR (reference), most groups showed higher CVD risk with adiposity fluctuations. For example, when PA decreased, CVD risk was 1.82 (95%CI = 1.53 to 2.18) if BMI decreased and 2.00 (1.72 to 2.33) if BMI increased. Decreasing PA was associated with higher ACM regardless of adiposity change (i.e. HR = 1.89 [1.25 to 2.87] if WHR increased). Conclusions: PA stability or increase was not associated with increased ACM risk, across adiposity change levels. Stable adiposity was not associated with increased CVD risk, if PA was stable or increased. Funding: National Health Medical Research Council Ideas Grant (APP 1180812).
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Copyright (c) 2021 Matthew N. Ahmadi, Susan Paudel, Jason M. R. Gill, Emmanuel Stamatakis
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