Distinct effects of different frequency active interruptions to sitting on glycemic control in Type 2 Diabetes
Oral Presentation A7.2
DOI:
https://doi.org/10.14288/hfjc.v14i3.400Keywords:
Sedentary Behaviour, Physical Activity, Glucose Metabolism, Type 2 Diabetes, Continuous Glucose MonitoringAbstract
Background: Active interruptions to sitting time are beneficial for glycemic control in adults with type 2 diabetes. With recent movements towards less prescriptive physical activity and sedentary behaviour guidelines, it is relevant to determine whether the frequency of interruptions to sitting time is important for health. The optimal frequency of active interruptions to sitting time is yet to be examined when total activity time is standardized. Purpose: To examine whether the frequency of interruptions to sitting time involving simple resistance activities (SRAs), compared to uninterrupted sitting, differentially affected 22 h glycemic control in adults with medication-controlled type 2 diabetes (T2D). Methods: Twenty-four participants (13 men; mean±SD age 62±8 years) completed three 8 h laboratory conditions: SIT: uninterrupted sitting; SRA3: sitting interrupted with 3 min of SRAs every 30 min; and, SRA6: sitting interrupted with 6 min of SRAs every 60 min. Flash glucose monitors assessed glycemic control over a 22 h period. Results: No differences were observed between conditions for overall 22 h glycemic control as measured by AUCtotal, mean glucose and time in hyperglycemia. During the 3.5 h post-lunch period, mean glucose was significantly lower during SRA6 (10.1 mmol.L-1, 95%CI 9.2, 11.0) compared to SIT (11.1 mmol.L-1, 95%CI 10.2, 12.0; P = 0.006). Post-lunch iAUCnet was significantly lower during SRA6 (6.2 mmol.h.L-1, 95%CI 3.3, 9.1) compared to SIT (9.9 mmol.h.L-1, 95%CI 7.0, 12.9; P = 0.003). Time in hyperglycemia was significantly lower post-lunch during SRA6 (1.5 h, 95%CI 1.0, 1.9, P = 0.001) compared to SIT (2.2 h, 95%CI 1.7, 2.6). Nocturnal mean glucose was significantly lower following the SRA3 condition (7.6 mmol.L-1, 95%CI 7.1, 8.1) compared to SIT (8.1 mmol.L-1, 95%CI 7.6, 8.7, P = 0.024). Conclusions: With standardized total activity time, less-frequent active interruptions to sitting may acutely improve glycemic control; while more-frequent interruptions may be beneficial for nocturnal glucose in those with medication-controlled T2D. Funding: This research was supported by a Heart Foundation Vanguard Grant (Award no. 101449), a NHMRC Centre of Research Excellence grant #1057608, and the Victorian Government OIS scheme.
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Copyright (c) 2021 Ashleigh R. Homer, Frances C. Taylor, Paddy C. Dempsey, Michael J. Wheeler, Parneet Sethi, Megan S. Grace, Daniel J. Green, Neale D. Cohen, Robyn N. Larsen, Bronwyn A. Kingwell, Neville Owen, David W. Dunstan
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